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Cat. Number
10-1128
Chemical Name
奥沙普秦 Oxaprozin
CAS Number
21256-18-8
Mol. Formula
C18H15NO3
Mol. Weight
293.32
Qty 1
10mg
Qty 2
50mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
4,5-Diphenyl-2-oxazolepropanoic acid
Solubility
Soluble in DMSO
Storage condition
RT
Stability
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
References

Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB pathway.2 The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 μmol/l), with consequent potent analgesic activity, and NF-κB activation in inflammatory cells (IC50 = 50 μmol/l).3

References/Citations
1) Merck 14:6924
2) Ottonello et al. (2009), Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway; Br. .J. Pharmacol., 157 294
3) Dallegri et al. (2005), A review of the emerging profile of the anti-inflammatory drug oxaprozin; Expert Opin .Pharmacother., 6 777

Focus Biomolecules cell signaling reagent supplier, chemical structure of Oxaprozin | NFkB inhibitor | CAS 21256-18-8

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