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Cat. Number
10-1104
Chemical Name
雷帕霉素 Rapamycin
CAS Number
53123-88-9
Mol. Formula
C51H79NO13
Mol. Weight
914.17
Qty 1
50mg
Qty 2
100mg
Appearance
White solid
Application Notes
98% NMR (Conforms)
Synonym
Sirolimus
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 90 mg/ml).
Storage condition
-20℃
Stability
Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
References

Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that binds to mTOR Complex1(mTORC1) inhibiting the mammalian target of rapamycin (mTOR).2Rapamycin also binds to mTORC2 leading to decreased glucose tolerance and insensitivity to insulin.3 Induces autophagy.4

References/Citations
1) Kay et al. (1991) Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology, 72544
2) Mita et al., (2003) The molecular target of rapamycin (mTOR) as a therapeutic target against cancer; Cancer Biol. Ther., 2(4 Suppl 1) S169
3) Lamming et al. ( 2012). Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity; Science, 335 1638
4) Sarkar et al. (2009), Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies; Cell Death and Differentiation, 1646

Focus Biomolecules cell signaling reagent supplier, chemical structure of Rapamycin | mTOR inhibitor | CAS 53123-88-9

雷帕霉素  英文名称Rapamycin ,货号10-1104 上海惠诚提供100mg 50mg 雷帕霉素 Rapamycin,美国focus原装进口,咨询电话021-60498804
雷帕霉素  英文名称Rapamycin ,货号10-1104 上海惠诚提供100mg 50mg 雷帕霉素 Rapamycin,美国focus原装进口,咨询电话021-60498804
 
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