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Cat. Number
10-1084
Chemical Name
格尔德霉素 Geldanamycin
CAS Number
30562-34-6
Mol. Formula
C29H40N2O9
Mol. Weight
560.65
Qty 1
1mg
Qty 2
5mg
Appearance
Yellow solid
Application Notes
98% by HPLC NMR (Conforms)
Synonym
NSC 122750; U-29135,9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate
Solubility
Soluble in DMSO (up to 50 mg/ml).
Storage condition
-20°C
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
References

Geldanamycin (30562-34-6) inhibits HSP90 by binding to its ATP-binding domain (Kd=1.2 μM) and subsequently inhibits HSP90 client proteins. Geldanamycin induces apoptosis in various cell types. Cell permeable.

References/Citations
1) Neckers et al. (1999), Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity; Invest. New Drugs, 17 361
2) Zang et al. (2006), HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis; Mol. Cell. Biochem., 281 111

Focus Biomolecules cell signaling reagent supplier, chemical structure Geldanamycin | HSP90 inhibitor | CAS 30562-34-6

格尔德霉素  英文名称Geldanamycin ,货号10-1084 上海惠诚提供1mg 5mg 格尔德霉素 Geldanamycin,美国focus原装进口,咨询电话021-60498804
格尔德霉素  英文名称Geldanamycin ,货号10-1084 上海惠诚提供1mg 5mg 格尔德霉素 Geldanamycin,美国focus原装进口,咨询电话021-60498804
 
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