您的位置:首页>>生化试剂>>小分子化合物>>咯利普兰 Rolipram
Cat. Number
10-1079
Chemical Name
咯利普兰 Rolipram
CAS Number
61413-54-5
Mol. Formula
C16H21NO3
Mol. Weight
275.35
Qty 1
10mg
Qty 2
50mg
Appearance
White or off-white solid
Application Notes
98% by TLC NMR conforms
Synonym
ZK 62711,4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (racemic)
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
References

Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.

References/Citations
1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535
2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460
3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837

Focus Biomolecules cell signaling reagent supplier, chemical structure of Rolipram | PDE4 inhibitor | CAS 61413-54-5

咯利普兰  英文名称Rolipram ,货号10-1079 上海惠诚提供10mg 50mg 咯利普兰 Rolipram,美国focus原装进口,咨询电话021-60498804

在线咨询 联系方式 二维码

服务热线

021-60498804

扫一扫,关注我们