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Cat. Number
10-1078
Chemical Name
舒尼替尼苹果酸 Sunitinib malate
CAS Number
341031-54-7
Mol. Formula
C22H27FN4O4 C4H6O5
Mol. Weight
532.57
Qty 1
10mg
Qty 2
50mg
Appearance
Orange solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
SU-11248,N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimehyl-1H-pyrrole-3-carboxamide malate
Solubility
Soluble in DMSO (up to 13 mg/ml).
Storage condition
-20°C
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
References

Sunitinib malate (341031-54-7) is a potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRβ and Kit (Ki = 2-17 nM)1. Also inhibits cFMS (IC50=7 nM)2 and FLT33. Potent inhibitor of angiogenesis4. Sunitinib malate is a clinically useful anticancer agent. Cell permeable.

References/Citations
1) Deeks et al. (2006), Sunitinib; Drugs, 66 2255
2) Guo et al. (2006), Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors; Mol. Cancer. Ther., 5 1007
3) O'Farrell et al. (2003), SU11248 is a novel FLT3 yrosine kinase with potent activity in vitro and in vivo; Blood, 101 3597
4) Roskoski et al. (2007), Sunitinib: a EGF and PDGF receptor protein kinase and angiogenesis inhibitor; Biochem. Biophys. Res. Commun., 356 323

Focus Biomolecules cell signaling reagent supplier, Sunitinib malate | VEGFR, PDGFR kinase inhibitor | CAS 341031-54-7

舒尼替尼苹果酸  英文名称Sunitinib malate ,货号10-1078 上海惠诚提供10mg 50mg 阿舒尼替尼苹果酸 Sunitinib malate,美国focus原装进口,咨询电话021-60498804

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