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Cat. Number
10-1067
Chemical Name
SAHA (Vorinostat )
CAS Number
149647-78-9
Mol. Formula
C14H20N2O3
Mol. Weight
264.33
Qty 1
50mg
Qty 2
250mg
Appearance
White solid
Application Notes
98% NMR (Conforms)
Synonym
Vorinostat,Suberoylanilide-hydroxamic acid
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml).
Storage condition
RT
Stability
Stable for 5 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
References

SAHA (149647-78-9) is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. SAHA synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.

References/Citations
1) Vrana et al. (1999), Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun and p21CIP1, but independent of p53; Oncogene, 18 7016
2) Butler et al. (2002), The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin; Proc. Natl. Acad. Sci. USA,99 11700
3) Tang et al. (2012), Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells, 13 567

 

Focus Biomolecules cell signaling reagent supplier, chemical structure of SAHA | HDAC inhibitor | CAS 149647-78-9

SAHA (Vorinostat ) ,货号10-1067 上海惠诚提供50mg 250mg SAHA (Vorinostat ),美国focus原装进口,咨询电话021-60498804

SAHA (Vorinostat ) ,货号10-1067 上海惠诚提供50mg 250mg SAHA (Vorinostat ),美国focus原装进口,咨询电话021-60498804

 

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