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Cat. Number
10-1061
Chemical Name
U-73122
CAS Number
112648-68-7
Mol. Formula
C29H40N2O3
Mol. Weight
464.65
Qty 1
5mg
Qty 2
25mg
Appearance
White or off-white solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
Solubility
Very soluble in Methylene chloride or Chloroform. Slightly soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 1 mg/ml).
Storage condition
RT
Stability
Stable for 1 year as supplied. Use caution when attempting to resuse stored DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that develop a pink color after storage should i
References

U-73122 (112648-68-7) inhibits receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction.1  U-73122 is a useful tool for probing the involvement of PI-PLC in receptor mediated cellular physiology and processes.2-4

References/Citations

1) Bleasdale et al. (1990), Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther., 255756
2) Zholos et al. (2004), Phospholipase C, but not InsP3 or DAG,-dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells; Br. J. Pharmacol., 141 23 
3) Jun et al. (2004), Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE dependent yeast vacuole fusion; J. Biol. Chem. ,279 53186
4) Fernandez-Ulibarri et al. (2007), Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway; Mol. Biol. Cell, 18 3250

U-73122 | 112648-68-7 | Structure | Supplier

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