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Cat. Number
10-1053
Chemical Name
米非司酮(RU486) Mifepristone (RU486)
CAS Number
84371-65-3
Mol. Formula
C29H35NO2
Mol. Weight
429.59
Qty 1
100mg
Qty 2
500mg
Appearance
Yellow solid
Application Notes
>98% by TLC
Synonym
RU486,11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage condition
RT
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
References

Mifepristone (84371-65-3) is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3.

References/Citations
1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses; Annu. Rev. Med. 48 129
2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins; J. Steroid Biochem. 31161
3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor; Exp. Cell Res. 147 177

Focus Biomolecules cell signaling reagent supplier, Mifepristone | RU486 | Glucocorticoid antagonist | CAS 84371-65-3

米非司酮(RU486)  英文名称Mifepristone (RU486)，货号10-1053 上海惠诚提供100mg 500mg 米非司酮(RU486) Mifepristone (RU486)，美国focus原装进口，咨询电话021-60498804
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