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| Cat. Number | 10-1037 |
| Chemical Name | ZM-447439 |
| CAS Number | 331771-20-1 |
| Mol. Formula | C29H31N5O4 |
| Mol. Weight | 513.59 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | White solid |
| Application Notes | 98% by TLC |
| Synonym | N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide |
| Solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml). |
| Storage condition | RT |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| References | ZM-447439 (331771-20-1) is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 μM, Aur C IC50 = 250 nM at physiological ATP concentrations2, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). ZM-447439 did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.1,2
References/Citations
ZM-447439 ，货号10-1037 上海惠诚提供5mg 25mg ZM-447439，美国focus原装进口，咨询电话021-60498804 |
下一个：喜树碱 Camptothecin上一个：ZM-336372 |
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