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Cat. Number
10-1026
Chemical Name
GF-109203X
CAS Number
133052-90-1
Mol. Formula
C25H24N4O2
Mol. Weight
412.49
Qty 1
5mg
Qty 2
25mg
Appearance
Orange solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
Go 6850; Bisindolylmaleimide I,2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Solubility
Soluble in DMSO (up to 10 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
References

GF-109203X (133052-90-1) is a potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 μM and phosphorylase kinase IC50= 0.7 μM). Inactive against the tyrosine kinases EGFR, PGDFR and Insulin receptor. Potent inhibitor of GSK-3β in cell lysates (IC50 = 360nM) and GSK-3β immunoprecipitates (IC50 = 170nM) derived from rat epididymal adipocytes.2 Cell permeable.

References/Citations
1) Toullec, et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol .Chem. 266 15771
2) Hers, et al. (1999) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity; FEBS Lett. 460 433

Focus Biomolecules cell signaling reagent supplier, chemical structure of GF-109203X | PKC inhibitor | CAS 133052-90-1

GF-109203X ,货号10-1026 上海惠诚提供5mg 25mg GF-109203X,美国focus原装进口,咨询电话021-60498804
GF-109203X ,货号10-1026 上海惠诚提供5mg 25mg GF-109203X,美国focus原装进口,咨询电话021-60498804
 
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