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Cat. Number
10-1012
Chemical Name
罗格列酮马来酸盐 Rosiglitazone Maleate
CAS Number
155141-29-0
Mol. Formula
C18H19N3O3S
Mol. Weight
357.43
Qty 1
10mg
Qty 2
50mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
Avandia; BRL49653,5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleate
Solubility
Soluble in DMSO (up to 50 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
References

      Rosiglitazone (155141-29-0) is a prototypical TZD antidiabetic agent. Potent and selective PPARg agonist (Kd=43 nM).1,2  Clinically useful antihyperglycemc agent.3  Induces a brown fat gene program in subcutaneous white adipose tissue via activation of the PRDM16 protein.4 Induces differentiation of pluripotent stem cells into adipocytes.5

References/Citations
1) Cantello et al. (1994), [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents; J. Med. Chem., 37 3977
2) Lehmann et al. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARgamma); J. Biol. Chem., 270 12953
3) Wilson et al. (1996), The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones; J. Med. Chem., 39665
4) Haruya et al. (2012), PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein; Cell Metab., 15 395
5) Ruiz-Ojeda et al. (2016), Cell Models and their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review; Int. J. Mol. Sci., 17 E1040

Focus Biomolecules cell signaling reagent supplier, structure of Rosiglitazone maleate | PPARγ agonist | CAS 155141-29-0

罗格列酮马来酸盐  英文名称Rosiglitazone Maleate ,货号10-1012 上海惠诚提供10mg 50mg 罗格列酮马来酸盐 Rosiglitazone Maleate,美国focus原装进口,咨询电话021-60498804
罗格列酮马来酸盐  英文名称Rosiglitazone Maleate ,货号10-1012 上海惠诚提供10mg 50mg 罗格列酮马来酸盐 Rosiglitazone Maleate,美国focus原装进口,咨询电话021-60498804
 
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