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| Cat. Number | S0132 |
| Chemical Name | Saikosaponin A |
| CAS Number | 20736-09-8 |
| Mol. Formula | C42H68O13 |
| Mol. Weight | 780.98 |
| Qty 1 |
1mg |
| Appearance | White Powder |
| Application Notes | ≥98% |
| Solubility | Soluble in DMSO |
| Storage condition | -20°C |
| References | Saikosaponin A is a triterpene saponin found in Bupleurum that exhibits anti-inflammatory, analgesic, neuromodulatory, anticancer, and immunosuppressive activities. Saikosaponin A decreases production of TNF-α, IL-1β, and IL-2 and increases mechanical withdrawal thresholds and thermal withdrawal thresholds in animal models of chronic constructive injury. Saikosaponin A also decreases self-administration of cocaine and morphine. In colon carcinoma cells, saikosaponin A causes activation of caspases 2, 3, 8, and 9 and PARP, induces apoptosis, and decreases expression of Bcl-2 and XIAP. Additionally, this compound inhibits the proliferation and activation of ConA-treated T cells, inducing G0/G1 phase cell cycle arrest and decreasing expression of TNF-α, IL-2, and IFN-γ.参考文献 Zhou X, Cheng H, Xu D, et al. Attenuation of Neuropathic Pain by Saikosaponin a in a Rat Model of Chronic Constriction Injury. Neurochem Res. 2014 Aug 9. [Epub ahead of print]. PMID: 25107300. Yoon SS, Seo JW, Ann SH, et al. Effects of saikosaponin A on cocaine self-administration in rats. Neurosci Lett. 2013 Oct 25;555:198-202. PMID: 24076136. Kim BM, Hong SH. Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. Apoptosis. 2011 Feb;16(2):184-97. PMID: 21107704. Sun Y, Cai TT, Zhou XB, et al. Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis. Int Immunopharmacol. 2009 Jul;9(7-8):978-83. PMID: 19375524. |
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