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| Cat. Number | S8044 |
| Chemical Name | R，S-莱菔硫烷 R,S-Sulforaphane |
| CAS Number | 4478-93-7 |
| Mol. Formula | C6H11NOS2 |
| Mol. Weight | 177.29 |
| Qty 1 |
25mg |
| Qty 2 | 50mg |
| Appearance | Slight yellowish liquid |
| Application Notes | ≥99% |
| Synonym | D,L-Sulforaphane, Sulforaphane, 4-(Methylsulfinyl)-butyl isothiocyanate |
| Solubility | Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. |
| Storage condition | -20°C |
| References | R,S-Sulforaphane is a synthetic isothiocyanate. R-Sulforaphane is the naturally-occurring isomer, found in broccoli. This compound exhibits antioxidative, neuroprotective, anti-inflammatory, anti-atherosclerotic, neuromodulatory, cardioprotective, anticoagulant, antibiotic, anticancer chemotherapeutic, and chemopreventive activities; research suggests that the R-isomer may be more bioactive than the S-isomer. R,S-Sulforaphane induces activity and expression of phase II enzymes, inhibits the aryl hydrocarbon receptor, and downregulates expression of HDACs and STAT5. 参考文献：
Lee JH, Jeong JK, Park SY. Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway. Neuroscience. 2014 Oct 10;278:31-9. PMID: 25130556. Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440. Nallasamy P, Si H, Babu PV, et al. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem. 2014 Aug;25(8):824-33. PMID: 24880493. Pinz S, Unser S, Rascle A. The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One. 2014 Jun 9;9(6):e99391. PMID: 24910998. Wu QQ, Zong J, Gao L, et al. Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy. Herz. 2014 May;39(3):390-6. PMID: 23784363. Kleszczyński K, Ernst IM, Wagner AE, et al. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013 Dec;78:28-40. PMID: 24121007. Chuang WY, Kung PH, Kuo CY, et al. Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemost. 2013 Jun;109(6):1120-30. PMID: 23426129. Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep. 2013 Apr;29(4):1671-7. PMID: 23404329. Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862. Wu HZ, Fei HJ, Zhao YL, et al. Antibacterial mechanism of sulforaphane on Escherichia coli. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):386-90. PMID: 22812243. Do DP, Pai SB, Rizvi SA, et al. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010 Feb 15;386(1-2):114-21. PMID: 19922783. |
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