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| Cat. Number | D8014 |
| Chemical Name | DU-14 |
| CAS Number | 186303-55-9 |
| Mol. Formula | C22H38N2O4S |
| Mol. Weight | 426.6 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | White to off white powder |
| Application Notes | ≥98% |
| Solubility | DMSO (25mg/ml) |
| Storage condition | 4°C |
| References | DU-14 inhibits steroid sulfatase, displaying neuromodulatory, anti-amnestic, and cognition enhancing activities. DU-14 inhibits the amnestic effects of scopolamine, likely enhancing cognitive function through increasing levels of excitatory neurosteroids. 参考文献： Babalola PA, Fitz NF, Gibbs RB, et al. The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract. Neurobiol Learn Mem. 2012 Oct;98(3):303-10. PMID: 23022361. Johnson DA, Wu T, Li P, et al. The effect of steroid sulfatase inhibition on learning and spatial memory. Brain Res. 2000 May 26;865(2):286-90. PMID: 10821934. Johnson DA, Rhodes ME, Boni RL, et al. Chronic steroid sulfatase inhibition by (p-O-sulfamoyl)-N-tetradecanoyl tyramine increases dehydroepiandrosterone sulfate in whole brain. Life Sci. 1997;61(24):PL 355-9. PMID: 9399636. |
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