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| Cat. Number | D5897 |
| Chemical Name | 盐酸多西环素 Doxycline hyclate |
| CAS Number | 24390-14-5 |
| Mol. Formula | (C22H24N2O8)2 • 2HCl • H2O • C2H6O |
| Mol. Weight | 512.9 |
| Qty 1 |
1g |
| Qty 2 | 5g |
| Appearance | Yellow crystal powder |
| Application Notes | ≥97% |
| Synonym | Doxycycline hydrochloride hemiethanolate hemihydrate, Atridox, Bassado, Clinofug, Doryx, Hydramycin, Mespafinn, Retens, Spanor, Unacil, Zadorin |
| Melting Pt. | 220-223°C |
| Solubility | Soluble in water 50 mg/mL; DMSO. |
| Storage condition | Ambient |
| References | Doxycycline is a tetracycline antibiotic that exhibits anti-parasitic, anti-helminthic, anti-inflammatory, anticancer, and anti-metastatic activities. Doxycycline exerts its antibacterial activity through binding 16S rRNA of the bacterial 30S ribosome, preventing binding of aminoacyl-tRNA to the ribosomal A site, inhibiting translation. Doxycycline also inhibits matrix metalloproteinases (MMPs). 参考文献: Joks R, Durkin HG. Non-antibiotic properties of tetracyclines as anti-allergy and asthma drugs. Pharmacol Res. 2011 Dec;64(6):602-9. PMID: 21501686. Dalvi PS, Singh A, Trivedi HR, et al. Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms. Ann Thorac Med. 2011 Oct;6(4):221-6. PMID: 21977068. Errami M, Galindo CL, Tassa AT, et al. Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice. J Pharmacol Exp Ther. 2008 Mar;324(3):1196-203. PMID: 18089841. Dahl EL, Shock JL, Shenai BR, et al. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep;50(9):3124-31. PMID: 16940111. Hoerauf A, Mand S, Fischer K, et al. Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol. 2003 Nov;192(4):211-6. PMID: 12684759. Dursun D, Kim MC, Solomon A, et al. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol. 2001 Jul;132(1):8-13. PMID: 11438047. Fife RS, Sledge GW Jr. Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells. J Lab Clin Med. 1995 Mar;125(3):407-11. PMID: 7897308. Fumoto T, Takeshita S, Ito M, Ikeda K. Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasis. J Bone Miner Res. 2014 Apr;29(4):830-842. PMID: 24014480. |
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