Diallyl trisulfide is an organosulfur compound initially found in garlic; it exhibits anticancer chemotherapeutic, immunostimulatory, antioxidative, hepatoprotective, anti-fibrotic, anti-estrogenic, anti-metastatic, anti-inflammatory, anti-angiogenic, and cardioprotective activities. In vivo, diallyl trisulfide inhibits lipid peroxidation, increases phase II enzymes such as catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase, and decreases arsenic-induced hepatic dysfunction. Diallyl trisulfide also decreases collagen deposition, hepatic stellate cell activation, fibrosis, and levels of procollagen I and α-SMA.

参考文献：

Suda S, Watanabe K, Tanaka Y, et al. Identification of molecular target of diallyl trisulfide in leukemic cells. Biosci Biotechnol Biochem. 2014;78(8):1415-7. PMID: 25130746.

Sumedha N, Miltonprabu S. Diallyl trisulfide ameliorates arsenic-induced hepatotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. Hum Exp Toxicol. 2014 Jul 25. [Epub ahead of print]. PMID: 25062976.

Hung FM, Shang HS, Tang NY, et al. Effects of diallyl trisulfide on induction of apoptotic death in murine leukemia WEHI-3 cells in vitro and alterations of the immune responses in normal and leukemic mice in vivo. Environ Toxicol. 2014 May 28. [Epub ahead of print]. PMID: 24890016.

Zhu X, Zhang F, Zhou L, et al. Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats. Naunyn Schmiedebergs Arch Pharmacol. 2014 May;387(5):445-55. PMID: 24557053.

Hahm ER, Singh SV. Diallyl trisulfide inhibits estrogen receptor-α activity in human breast cancer cells. Breast Cancer Res Treat. 2014 Feb;144(1):47-57. PMID: 24487688.

Shin DY, Cha HJ, Kim GY, et al. Inhibiting invasion into human bladder carcinoma 5637 cells with diallyl trisulfide by inhibiting matrix metalloproteinase activities and tightening tight junctions. Int J Mol Sci. 2013 Oct 1;14(10):19911-22. PMID: 24084732.

Wallace GC 4th, Haar CP, Vandergrift WA 3rd, et al. Multi-targeted DATS prevents tumor progression and promotes apoptosis in ectopic glioblastoma xenografts in SCID mice via HDAC inhibition. J Neurooncol. 2013 Aug;114(1):43-50. PMID: 23754639.

Lee HJ, Lee HG, Choi KS, et al. Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-κB and STAT3 as potential targets. Biochem Biophys Res Commun. 2013 Jul 26;437(2):267-73. PMID: 23811270.

Li Y, Zhang J, Zhang L, et al. Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. Carcinogenesis. 2013 Jul;34(7):1601-10. PMID: 23430952.

Huang YT, Yao CH, Way CL, et al. Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats. J Appl Physiol (1985). 2013 Feb;114(3):402-10. PMID: 23139364.