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| Cat. Number | D3200 |
| Chemical Name | 蛇形菌素 Diacetoxyscirpenol |
| CAS Number | 2270-40-8 |
| Mol. Formula | C19H26O7 |
| Mol. Weight | 366.41 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | White powder |
| Application Notes | ≥98% |
| Synonym | Anguidin, Anguidine |
| Melting Pt. | 160-164°C |
| Solubility | Insoluble in water. Soluble in methanol (10 mg/mL), and acetone. |
| Storage condition | 4°C |
| References | Diacetoxyscirpenol (DAS) is a type A trichothecene mycotoxin initially produced by species of Fusarium. DAS primarily exhibits immunosuppressive and, potentially, anticancer activities; it is cytotoxic to most cell types and tissues in vivo. 参考文献： Jun DY, Kim JS, Park HS, et al. Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells. Toxicol Appl Pharmacol. 2007 Jul 15;222(2):190-201. PMID: 17559898. Nasri T, Bosch RR, Voorde St, et al. Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. Toxicol In Vitro. 2006 Sep;20(6):832-40. PMID: 16472964. Ayral AM, Dubech N, Le Bars J, et al. In vitro effect of diacetoxyscirpenol and deoxynivalenol on microbicidal activity of murine peritoneal macrophages. Mycopathologia. 1992 Nov;120(2):121-7. PMID: 1336129. Coppock RW, Gelberg HB, Hoffmann WE, et al. The acute toxicopathy of intravenous diacetoxyscirpenol (anguidine) administration in swine. Fundam Appl Toxicol. 1985 Dec;5(6 Pt 1):1034-49. PMID: 4092867. |
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