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| Cat. Number | C4759 |
| Chemical Name | 氯氮平N-氧化物 Clozapine N-oxide |
| CAS Number | 34233-69-7 |
| Mol. Formula | C18H19ClN4O |
| Mol. Weight | 342.82 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Yellow Powder |
| Application Notes | ≥98% |
| Synonym | CNO |
| Melting Pt. | 212.0-214.0 |
| Solubility | Water to 10 mM, DMSO to 10 mg/mL, acetone, ether, methanol. |
| Storage condition | Ambient |
| References | Clozapine-N-oxide is a ligand that activates engineered GPCRs called “receptors activated solely by synthetic ligands” (RASSLs) or “designer receptors exclusively activated by designer drugs” (DREADDs); this allows for the studying of GPCR signaling control in vitro and in vivo. 参考文献： Li JH, Jain S, McMillin SM, et al. A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology. 2013 Oct;154(10):3539-51. PMID: 23861369. Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. PMID: 23769625. Farrell MS, Pei Y, Wan Y, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology. 2013 Apr;38(5):854-62. PMID: 23303063. Alvarez-Curto E, Prihandoko R, Tautermann CS, et al. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol. 2011 Dec;80(6):1033-46. PMID: 21880827. Francis TC, Chandra R, Friend DM, et al. Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress. Biol Psychiatry. 2015 Feb 1;77(3):212-222. PMID: 25173629. |
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