Fenticonazole is an imidazole derivative that exhibits antifungal, antibacterial, and anti-parasitic activities. Fenticonazole inhibits secretion of proteinase, potentially through antagonism of glucosamine-6-phosphate synthase; it also damages fungal cytoplasmic membranes and inhibits cytochrome oxidases and peroxidases. Fenticonazole displays antimicrobial activity against a variety of organisms, including species of Candida, Trichomonas, and gram positive bacteria. This compound may inhibit 14-α demethylase.
参考文献：
Veraldi S, Milani R. Topical fenticonazole in dermatology and gynaecology: current role in therapy. Drugs. 2008;68(15):2183-94. PMID: 18840006.
Fernández-Alba J, Valle-Gay A, Dibildox M, et al. Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen. J Chemother. 2004 Apr;16(2):179-86. PMID: 15216954.
Palacín C, Tarragó C, Agut J, et al. In vitro activity of sertaconazole, fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole against pathogenic vaginal yeast isolates. Methods Find Exp Clin Pharmacol. 2001 Mar;23(2):61-4. PMID: 11484411.
Milewski S, Mignini F, Covelli I, et al. Specific inhibition of acid proteinase secretion in Candida albicans by Lys-Nva-FMDP. J Med Vet Mycol. 1994;32(1):1-11. PMID: 8207618.
Graziani G, Cazzulani P. Irritation and toxicity studies with fenticonazole applied topically to the skin and mucous membranes. Arzneimittelforschung. 1981;31(12):2152-4. PMID: 7199317.
