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/ Products Classification 点击展开+Cat. Number | C2844 |
Chemical Name | 氯霉素 Chloramphenicol |
CAS Number | 56-75-7 |
Mol. Formula | C11H12Cl2N2O5 |
Mol. Weight | 323.13 |
Qty 1 |
5g |
Qty 2 | 10g |
Appearance | White or Yellowish White Crystalline Powder |
Application Notes | ≥98% |
Synonym | Chloromyxin, Ophthochlor, Ophthocort. |
Melting Pt. | 150.5-151.5°C |
Solubility | Slightly soluble in water (2.5 mg/mL). Very soluble in methanol, ethanol, ethyl acetate, acetone. |
Storage condition | Ambient |
References | Chloramphenicol is an antibiotic compound that binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Chloramphenicol exhibits antibacterial activity against Streptomyces. 参考文献: Sheth A, Escobar-Alvarez S, Gardner J, et al. Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death Dis. 2014 Mar 27;5:e1152. PMID: 24675470. Rajesh T, Song E, Lee BR, et al. Increased sensitivity to chloramphenicol by inactivation of manB in Streptomyces coelicolor. J Microbiol Biotechnol. 2012 Oct;22(10):1324-9. PMID: 23075781. Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523. |