您的位置:首页>>生化试剂>>小分子化合物>>氯霉素 Chloramphenicol
Cat. Number
C2844
Chemical Name
氯霉素 Chloramphenicol
CAS Number
56-75-7
Mol. Formula
C11H12Cl2N2O5
Mol. Weight
323.13
Qty 1
5g
Qty 2
10g
Appearance
White or Yellowish White Crystalline Powder
Application Notes
≥98%
Synonym
Chloromyxin, Ophthochlor, Ophthocort.
Melting Pt.
150.5-151.5°C
Solubility
Slightly soluble in water (2.5 mg/mL). Very soluble in methanol, ethanol, ethyl acetate, acetone.
Storage condition
Ambient
References

Chloramphenicol is an antibiotic compound that binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Chloramphenicol exhibits antibacterial activity against Streptomyces.

参考文献:

Sheth A, Escobar-Alvarez S, Gardner J, et al. Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death Dis. 2014 Mar 27;5:e1152. PMID: 24675470.

Rajesh T, Song E, Lee BR, et al. Increased sensitivity to chloramphenicol by inactivation of manB in Streptomyces coelicolor. J Microbiol Biotechnol. 2012 Oct;22(10):1324-9. PMID: 23075781.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

在线咨询 联系方式 二维码

服务热线

021-60498804

扫一扫,关注我们