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Cat. Number
H9726
Chemical Name
Hygromycin B
CAS Number
31282-04-9
Mol. Formula
C20H37N3O13
Mol. Weight
527.52
Qty 1
50 mg
Appearance
Buff Powder
Application Notes
≥95%
Storage condition
Ambient
References

Hygromycin B is an antibiotic that also displays antiviral activity. Hygromycin binds the 30S ribosomal subunit, inhibiting protein and RNA synthesis of bacteria or viruses; it induces misreadings at multiple steps in protein translation and suppresses translocation. In animal models, hygromycin B allows translation to occur but prevents formation of viral antigen by Leishmania and, separately, prevents infection by murine hepatitis virus.

参考文献:

Brodersen DE, Clemons WM Jr, Carter AP, et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. PMID: 11163189.

Ro YT, Scheffter SM, Patterson JL. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites. J Virol. 1997 Dec;71(12):8991-8. PMID: 9371555.

Macintyre G, Woods DE, Anderson R. Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob Agents Chemother. 1991 Dec;35(12):2630-3. PMID: 1667257.

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