Methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate

Loganin is an iridoid glucoside found in the Cornus officialis plant. Loganin displays anti-inflammatory, antioxidative, cognition enhancing, and neuroprotective activities. Loganin inhibits β-secretase in vitro and increases performance in Morris water maze and Y-maze tests in vivo, suggesting potential benefit in memory impairment and Alzheimer’s disease. This compound also modulates ERK signaling to decrease connective tissue growth factor and downregulates expression of MCP-1, NF-κB, and iNOS in animal models.

References

Youn K, Jeong WS, Jun M. β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus. Nat Prod Res. 2013 Aug;27(16):1471-4. PMID: 22931211.

Jiang WL, Zhang SP, Hou J, et al. Effect of loganin on experimental diabetic nephropathy. Phytomedicine. 2012 Feb 15;19(3-4):217-22. PMID: 21978885.

Park CH, Tanaka T, Kim JH, et al. Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology. 2011 Nov 28;290(1):14-21. PMID: 21864639.

Kwon SH, Kim HC, Lee SY, et al. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol. 2009 Oct 1;619(1-3):44-9. PMID: 19666019.

Cat. Number	L5624
Chemical Name	Methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
CAS Number	18524-94-2
Mol. Formula	C17H26O10
Mol. Weight	390.38
Qty 1	10mg
Appearance	White to off white powder
Application Notes	≥98%
Synonym	7-Hydroxy-6-desoxyverbenalin, (1S,4aS,6S,7R,7aS)-6-Hydroxy-1-((1S,4R,5S)-5-hydroxy-4-(S)-hydroxy-3-(R)-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-methyl-1,4a,5,6,7,7a-hexahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester
Storage condition	Ambient
References	Loganin is an iridoid glucoside found in the Cornus officialis plant. Loganin displays anti-inflammatory, antioxidative, cognition enhancing, and neuroprotective activities. Loganin inhibits β-secretase in vitro and increases performance in Morris water maze and Y-maze tests in vivo, suggesting potential benefit in memory impairment and Alzheimer’s disease. This compound also modulates ERK signaling to decrease connective tissue growth factor and downregulates expression of MCP-1, NF-κB, and iNOS in animal models. References Youn K, Jeong WS, Jun M. β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus. Nat Prod Res. 2013 Aug;27(16):1471-4. PMID: 22931211. Jiang WL, Zhang SP, Hou J, et al. Effect of loganin on experimental diabetic nephropathy. Phytomedicine. 2012 Feb 15;19(3-4):217-22. PMID: 21978885. Park CH, Tanaka T, Kim JH, et al. Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology. 2011 Nov 28;290(1):14-21. PMID: 21864639. Kwon SH, Kim HC, Lee SY, et al. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol. 2009 Oct 1;619(1-3):44-9. PMID: 19666019.
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