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| Cat. Number | C0167 |
| Chemical Name | 甘珀 Carbenoxolone |
| CAS Number | 5697-56-3 |
| Mol. Formula | C34H50O7 |
| Mol. Weight | 570.76 |
| Qty 1 |
1g |
| Qty 2 | 5g |
| Appearance | White to off white powder |
| Application Notes | ≥97% |
| Melting Pt. | 292.8°C |
| Solubility | 100 mg/ 550 µL DMSO; 100 mg/ 3 mL Ethanol |
| Storage condition | Ambient |
| References | Carbenoxolone is a synthetic derivative of the active component of licorice (Glycyrrhiza glabra) and is most well known for its ability to inhibit gap junction connexin channels and 11β-hydroxysteroid dehydrogenase. Carbenoxolone displays a wide variety of beneficial properties, including neuroprotective, anti-inflammatory, and anti-obesity activities. 参考文献： Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920. Okuda H, Nishida K, Higashi Y, et al. NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death. Life Sci. 2013 Apr 19;92(13):808-14. PMID: 23454167. Oishi S, Sasano T, Tateishi Y, et al. Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels. J Pharmacol Sci. 2012;120(4):296-304. PMID: 23196902. Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899. Sano S, Nakagawa Y, Yamaguchi R, et al. Carbenoxolone alters the morphology of adipose tissues and downregulates genes involved in adipogenesis, glucose transport and lipid metabolism in high-fat diet-fed mice. Horm Metab Res. 2012 Jan;44(1):15-20. PMID: 22205568. Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952. |
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