1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)- amino]-2-propanol tartrate_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

Metoprolol is an inhibitor of β1-adrenergic receptors that exhibits antihypertensive, cardioprotective, anti-anginal, class II anti-arrhythmic, anti-atherosclerotic, anti-inflammatory, anticonvulsant/antiepileptic, and pro-angiogenic activities. Metoprolol is clinically used to treat hypertension, myocardial infarction, tachycardia, and congestive heart failure (CHF). In animal models of atherosclerosis, metoprolol decreases levels of TNF-α and CXCL1, infiltration of macrophages, and size of atherosclerotic plaques. This compound also inhibits seizures in animal models and, separately, increases microvessel sprouting in aortic rings.

References

Ulleryd MA, Bernberg E, Yang LJ, et al. Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE(-/-) Mice. Biomed Res Int. 2014;2014:548783. PMID: 25105129.

Borowicz KK, Banach M. Antiarrhythmic drugs and epilepsy. Pharmacol Rep. 2014 Aug;66(4):545-51. PMID: 24948053.

Stati T, Musumeci M, Maccari S, et al. β-Blockers promote angiogenesis in the mouse aortic ring assay. J Cardiovasc Pharmacol. 2014 Jul;64(1):21-7. PMID: 24621648

Cat. Number	M1879
Chemical Name	1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)- amino]-2-propanol tartrate
CAS Number	56392-17-7
Mol. Formula	(C15H25NO3)2 • C4H6O6
Mol. Weight	684.82
Qty 1	5g
Appearance	White Crystal Powder
Application Notes	≥98%
Synonym	Beloc, Betaloc, Lopressor, Prelis, Seloken, Selopral, Selo-Zok
Solubility	Soluble in water, methanol, ethanol, DMSO, or chloroform.
Storage condition	Ambient
References	Metoprolol is an inhibitor of β1-adrenergic receptors that exhibits antihypertensive, cardioprotective, anti-anginal, class II anti-arrhythmic, anti-atherosclerotic, anti-inflammatory, anticonvulsant/antiepileptic, and pro-angiogenic activities. Metoprolol is clinically used to treat hypertension, myocardial infarction, tachycardia, and congestive heart failure (CHF). In animal models of atherosclerosis, metoprolol decreases levels of TNF-α and CXCL1, infiltration of macrophages, and size of atherosclerotic plaques. This compound also inhibits seizures in animal models and, separately, increases microvessel sprouting in aortic rings. References Ulleryd MA, Bernberg E, Yang LJ, et al. Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE(-/-) Mice. Biomed Res Int. 2014;2014:548783. PMID: 25105129. Borowicz KK, Banach M. Antiarrhythmic drugs and epilepsy. Pharmacol Rep. 2014 Aug;66(4):545-51. PMID: 24948053. Stati T, Musumeci M, Maccari S, et al. β-Blockers promote angiogenesis in the mouse aortic ring assay. J Cardiovasc Pharmacol. 2014 Jul;64(1):21-7. PMID: 24621648
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