Oligomycin A_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

Oligomycin A is a macrolide antibiotic initially produced by several species of Streptomyces. Oligomycin A inhibits mitochondrial F1F0 ATP synthase, binding the F0 subunit, inhibiting ATP synthesis. Oligomycin A exhibits antifungal activity against species of Aspergillus, Alternaria, Botrytis, and Phytophthora; it also displays antibacterial efficacy against a variety of bacteria. Additionally, this compound displays anticancer potential, as it triggers inositol-requiring enzyme a (IRE1) signaling in cervical cancer cells, resulting in XBP1 splicing, CHOP expression, DR5 upregulation, and ultimately apoptosis. Oligomycin also alters expression of Bcl-2 proteins in glioma cells.

References

He L, Jang JH, Choi HG, et al. Oligomycin A enhances apoptotic effect of TRAIL through CHOP-mediated death receptor 5 expression. Mol Carcinog. 2013 Feb;52(2):85-93. PMID: 23335397.

Ponnala S, Chetty C, Veeravalli KK, et al. Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells. Int J Oncol. 2012 Feb;40(2):509-18. PMID: 22076676.

Yang PW, Li MG, Zhao JY, et al. Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus. Folia Microbiol (Praha). 2010 Jan;55(1):10-6. PMID: 20336498

Cat. Number	O4531
Chemical Name	Oligomycin A
CAS Number	579-13-5
Mol. Formula	C45H74O11
Mol. Weight	791.06
Qty 1	1mg
Appearance	White to off white powder
Application Notes	≥97%, TLC, HPLC
Solubility	Soluble in DMSO, ethanol, acetone.
Storage condition	4°C
References	Oligomycin A is a macrolide antibiotic initially produced by several species of Streptomyces. Oligomycin A inhibits mitochondrial F1F0 ATP synthase, binding the F0 subunit, inhibiting ATP synthesis. Oligomycin A exhibits antifungal activity against species of Aspergillus, Alternaria, Botrytis, and Phytophthora; it also displays antibacterial efficacy against a variety of bacteria. Additionally, this compound displays anticancer potential, as it triggers inositol-requiring enzyme a (IRE1) signaling in cervical cancer cells, resulting in XBP1 splicing, CHOP expression, DR5 upregulation, and ultimately apoptosis. Oligomycin also alters expression of Bcl-2 proteins in glioma cells. References He L, Jang JH, Choi HG, et al. Oligomycin A enhances apoptotic effect of TRAIL through CHOP-mediated death receptor 5 expression. Mol Carcinog. 2013 Feb;52(2):85-93. PMID: 23335397. Ponnala S, Chetty C, Veeravalli KK, et al. Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells. Int J Oncol. 2012 Feb;40(2):509-18. PMID: 22076676. Yang PW, Li MG, Zhao JY, et al. Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus. Folia Microbiol (Praha). 2010 Jan;55(1):10-6. PMID: 20336498
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