| Cat. Number | P6858 |
| Chemical Name | N-(1-Methylethyl)-4-[(2- methylhydrazino)methyl]- benzamide hydrochloride |
| CAS Number | 366-70-1 |
| Mol. Formula | C12H19N3O • HCl |
| Mol. Weight | 257.76 |
| Qty 1 |
100mg |
| Appearance | White crystalline powder |
| Application Notes | ≥97% |
| Synonym | Matulane, Natulan |
| Solubility | Soluble in water. |
| Storage condition | Ambient |
| References | Procarbazine is a hydrazine derivative that exhibits anticancer chemotherapeutic activity. Procarbazine acts as a DNA alkylator and induces double stranded DNA breaks and causes oxidative damage. Clinically, procarbazine is used to treat Hodgkin’s lymphoma and brain cancers. This compound also inhibits monoamine oxidase (MAO). References Ogawa K, Hiraku Y, Oikawa S, et al. Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II). Mutat Res. 2003 Aug 5;539(1-2):145-55. PMID: 12948823. Kyrtopoulos SA, Anderson LM, Chhabra SK, et al. DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance. Cancer Detect Prev. 1997;21(5):391-405. PMID: 9307842. |
