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| Cat. Number | R1776 |
| Chemical Name | 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)- |
| CAS Number | 501-36-0 |
| Mol. Formula | C14H12O3 |
| Mol. Weight | 228.24 |
| Qty 1 |
100mg |
| Appearance | White Powder |
| Application Notes | ≥98% |
| Synonym | 3,4',5-Stilbenetrio, 3,4',5-Trihydroxystilbene |
| Solubility | Soluble in DMSO and ethanol |
| Storage condition | -20°C |
| References | Resveratrol and its metabolites are phenolic phytoalexins found in several plants such as soybeans, peanuts, blueberries, mulberries, and grapes. Resveratrol is most well known for its antioxidative effects and activation of SIRT1, both contributing to its cardioprotective, anticancer chemotherapeutic, chemopreventive, anti-aging, anti-inflammatory, and antiviral activities; it also acts as a phytoestrogen. Resveratrol reversibly inhibits MAO as well as synaptosomal 5-HT and NE uptake, indicating potential antidepressant activity. This compound also shows benefit in in vitro and in vivo models of Alzheimer’s disease, degrading amyloid-β (Aβ) plaques, increasing brain cysteine levels, and decreasing brain glutathione levels; these effects may be dependent on resveratrol’s activation of AMPK and/or proteasomes. References Mohar DS, Malik S. The Sirtuin System: The Holy Grail of Resveratrol? J Clin Exp Cardiolog. 2012 Nov;3(11). 216. PMID: 23560248. Vingtdeux V, Giliberto L, Zhao H, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. 2010 Mar 19;285(12):9100-13. PMID: 20080969. Karuppagounder SS, Pinto JT, Xu H, et al. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int. 2009 Feb;54(2):111-8. PMID: 19041676. Athar M, Back JH, Tang X, et al. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):274-83. PMID: 17306316. Yáñez M, Fraiz N, Cano E, et al. Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity. Biochem Biophys Res Commun. 2006 Jun 2;344(2):688-95. PMID: 16631124. Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 2005 Nov 11;280(45):37377-82. PMID: 16162502. Narayanan N, Nargi D, Randolph C, et al. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009 Feb 6;125(1):1-8. PMID: 19326431. Huang A, Yang YM, Yan C, et al. Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. Diabetes. 2012 Dec;61(12):3181-3188. PMID: 22933112. Back JH, Rezvani HR, Zhu Y, et al. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1. J Biol Chem. 2011 May 27;286(21):19100-19108. PMID: 21471201. |
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