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| Cat. Number | A5044 |
| Chemical Name | 苯磺酸氨氯地平,Amlodipine besylate |
| CAS Number | 111470-99-6 |
| Mol. Formula | C20H25ClN2O5 • C6H5SO3H |
| Mol. Weight | 567.06 |
| Qty 1 |
1g |
| Qty 2 | 10g |
| Appearance | Almost White Crystal Powder |
| Synonym | Amlodipine Benzenesulfonate, Amlor, Istin, Monopina, Norvasc,2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4- dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate |
| Melting Pt. | 195-204°C |
| Solubility | Slightly soluble in water. Sparingly soluble in ethanol. soluble in DMSO(113mg/ml) |
| Storage condition | Ambient |
| References | Amlodipine is a dihydropyridine L-type Ca2+ channel blocker that exhibits antihypertensive, anti-anginal, and vasodilatory activities. Amlodipine is clinically used to treat hypertension and angina as it induces relaxation of arterial smooth muscles, decreases blood pressure, and increases blood flow to the heart. Amlodipine also inhibits acid sphingomyelinase (FIASMA), which is involved in programmed cell death. Additionally, this compound improves smooth muscle hypertrophy and collagen deposition, preventing arterial remodeling in hypertensive rats. 参考文献： Chen JL, Shang QH, Hu W, et al. Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. J Geriatr Cardiol. 2012 Jun;9(2):185-91. PMID: 22916067. Kornhuber J, Tripal P, Reichel M, et al. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010;26(1):9-20. PMID: 20502000. Wang JG. A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention. Vasc Health Risk Manag. 2009;5:593-605. PMID: 19688100. |
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