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| Cat. Number | A4443 |
| Chemical Name | L（+）蒜氨酸,L(+)Alliin |
| CAS Number | 556-27-4 |
| Mol. Formula | C6H11NO3S |
| Mol. Weight | 177.22 |
| Qty 1 |
25mg |
| Qty 2 | 50mg |
| Appearance | Colorless crystalline solid |
| Application Notes | ≥98% |
| Synonym | S-Allyl-L-cysteine sulfoxide, 3-(Allylsulfinyl)alanin, Alliin, EINECS 209-118-93-[(S)-2-Propenylsulfinyl]-L-alanine, S-Allyl-L-cysteine-S-oxide, |
| Melting Pt. | 164-166°C |
| Solubility | Soluble in water, PBS (10 mg/mL). Insoluble in ethanol, or acetone. |
| Storage condition | -20℃ |
| References | L-(+)-Alliin is a cysteine derivative originally found in Allium sativum (garlic); it exhibits anti-inflammatory, neuromodulatory, anti-diabetic, anti-hyperlipidemic, antioxidative, cardioprotective, and anti-angiogenic activities; it is the optically active and orally bioavailable isomer of alliin. In adipocytes, L-alliin inhibits LPS-stimulated activation of ERK1/2 and increases in inflammatory signaling. In animal models of myocardial infarction, L-alliin increases activity of superoxide dismutase, glutathione peroxidase, catalase, and glutathione-S-transferase. L-Alliin also activates NMDA-R subunits NR2A and NR2B. In diabetic rats, this compound decreases levels of LDL, VLDL, glucose, triglycerides, total cholesterol, and total lipids. Additionally, L-alliin inhibits VEGF-induced angiogenesis and FGF2 and VEGF secretion in fibrosarcoma cells. 参考文献： Ieong Tou W, Chang SS, Wu D, et al. Molecular level activation insights from a NR2A/NR2B agonist. J Biomol Struct Dyn. 2014;32(5):683-93. PMID: 23600691. Quintero-Fabián S, Ortuño-Sahagún D, Vázquez-Carrera M, et al. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators Inflamm. 2013;2013:381815. PMID: 24453416. Nasim SA, Dhir B, Kapoor R, et al. Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats. Pharm Biol. 2011 Apr;49(4):416-21. PMID: 21391887. Sangeetha T, Darlin Quine S. Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol induced cardiotoxicity in male Wistar rats: a histopathological study. Mol Cell Biochem. 2009 Aug;328(1-2):1-8. PMID: 19262997. Mousa AS, Mousa SA. Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutr Cancer. 2005;53(1):104-10. PMID: 16351512. |
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