| Cat. Number | T9946 |
| Chemical Name | Tylosin phosphate |
| CAS Number | 1405-53-4 |
| Mol. Formula | C46H77NO17 • H3PO4 |
| Mol. Weight | 1014.11 |
| Qty 1 |
1g |
| Appearance | White to almost white powder |
| Application Notes | ≥90% |
| Synonym | Farmazin TB, Tylosin phophate salt |
| Storage condition | Ambient |
| References | Tylosin is a macrolide antibiotic originally produced by Streptomyces. Like other macrolides, tylosin binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Tylosin displays antibacterial efficacy against most gram positive and some gram negative bacteria such as Campylobacter. 参考文献：Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742. Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855. |
