服务热线
021-60498804
| Cat. Number | A0933 |
| Chemical Name | 阿维A Acitretin |
| CAS Number | 55079-83-9 |
| Mol. Formula | C21H26O3 |
| Mol. Weight | 326.43 |
| Qty 1 |
25mg |
| Qty 2 | 100mg |
| Appearance | Yellow to green-yellow crystalline powder |
| Application Notes | ≥98%, multiple isomers |
| Synonym | Neotigason, Soriatane,9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid |
| Storage condition | -20°C |
| References | 阿维A ,Acitretin is an orally bioavailable retinoid that displays anti-inflammatory activity and is used clinically to treat psoriasis. Acitretin is a metabolite of etretinate that displays more optimized pharmacokinetic parameters. This compound activates all retinoic acid receptor subtypes (RARα/β/γ) without binding the receptor itself and also increases cAMP-PKA binding in erythrocytes. 参考文献：
Niu X, Cao W, Ma H, et al. Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. J Dermatol. 2012 Nov;39(11):916-21. PMID: 22913391. Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139. Raynaud F, Gerbaud P, Bouloc A, et al. Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit. J Invest Dermatol. 1993 Jan;100(1):77-81. PMID: 8380830. |
下一个： 放线酰胺素 Actinonin上一个：玉米赤霉烯酮 Zearalenone |
|
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
