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Cat. Number
TNFB
Chemical Name
TNFB,TNF beta Protein, Human, Recombinant
References

TNFB,TNF beta Protein, Human, Recombinant,淋巴毒素-α,也称为LT-α,TNF-β,肿瘤坏死因子配体超家族成员1,LTA TNFSF1和TNFB,是属于肿瘤坏死因子家族的分泌蛋白。 TNF-β/ TNFSF1 /淋巴毒素α是高度可诱导的,分泌的,并且作为同源三聚体分子存在。

上海惠诚生物提供IL-1F5 Protein, Human, Recombinant (Native) 以及各类细胞因子,同时推出CHO稳定细胞株开发技术服务方案,详情咨询电话021-60498804.

 

 Background Information:

Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.

名称 纯度 宿主 种属 内毒素
TNFB >97% E. coli Human /

 

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上海惠诚生物提供IL-1F5 Protein, Human, Recombinant (Native) 以及各类细胞因子,同时推出CHO稳定细胞株开发技术服务方案,详情咨询电话021-60498804.


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