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名称
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纯度
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宿主
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种属
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内毒素
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IL-2
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> 95 %
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E. coli
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human
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/
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IL-2(Interleukin-2 )是一种白介素，是免疫系统中的一类细胞生长因子，能调控免疫系统中白血球的细胞活性，促进Th0和CTL的增殖，也参与抗体反应、造血和肿瘤监视。
IL2 Background Information:
Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to theIL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced bymacrophages, facilitates IL-2 production by T lymphocytes (T cells).
Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.
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常用因子
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规格
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价格
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制备周期
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标签
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IL-2
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1mg
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¥870.00
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备货
|
untagged
|
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bFGF
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1mg
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¥870.00
|
备货
|
untagged
|
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aFGF
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1mg
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¥870.00
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备货
|
untagged
|
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FN
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1mg
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¥870.00
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备货
|
his tag
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IL-15
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1mg
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¥5,220.00
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备货
|
his tag
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IL-16
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1mg
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¥3,480.00
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一周
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his tag
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SCF
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1mg
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¥6,090.00
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备货
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his tag
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转铁蛋白（牛）
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1g
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¥696.00
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备货
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天然（牛源）
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IL1A
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1mg
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¥6,090.00
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货期4周
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untagged
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IL1B
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1mg
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¥6,090.00
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货期4周
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untagged
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IL1RA
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1mg
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¥6,090.00
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货期4周
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untagged
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IL1F5
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1mg
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¥6,090.00
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货期4周
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untagged
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IL1F6
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1mg
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¥6,090.00
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货期4周
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untagged
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IL1F7
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1mg
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¥6,090.00
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货期4周
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untagged
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IL1F8
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1mg
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¥6,090.00
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货期4周
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untagged
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IL1F9
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1mg
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¥6,090.00
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货期4周
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untagged
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上海惠诚生物科技有限公司成立于2010年，历经9年多的积累，现推出CHO稳定细胞株开发技术服务方案，详情请咨询电话021-60498804.
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