芘亚磷酰胺 dU Pyrene phosphoramidite dU_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

芘亚磷酰胺 dU Pyrene phosphoramidite dU

Chemical Name

芘亚磷酰胺 dU Pyrene phosphoramidite dU

Mol. Formula

C57H55N4O8P

Mol. Weight

955.04

Qty 1

250mg

Qty 2

Appearance

yellowish foam

Solubility

good in dichloromethane and acetonitrile

Storage condition

-20°C

References

Pyrene is polycyclic aromatic hydrocarbon which is well-known for its ability to intercalate into DNA. Pyrene features intense blue fluorescence. Its parameters depend strongly on fluorophore microenvironment. Therefore, fluorescence spectra of pyrene are used for the extraction of structural information about site surrounding pyrene. Two pyrenes in close proximity usually form excimers easily detectable by excimer fluorescence. Pyrene can also be a FRET donor to other fluorophores such as perylene.

With this phosphoramidite, pyrene can be introduced into DNA or RNA by means of automated synthesis. This pyrene phosphoramidite contains hydrocarbon moiety rigidly attached to deoxyuridine. This reagent allows to attach pyrene fragment to 5', internal, or 3' position (using universal support).

This amidite requires no special handling, coupling, or deprotection conditions. Recommended diluent for it is acetonitrile.

Pyrene dU amidite