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Cat. Number
DMS(O)MT 氨基连接臂 C6 DMS(O)MT aminolink C6
Chemical Name
DMS(O)MT 氨基连接臂 C6 DMS(O)MT aminolink C6
Mol. Formula
C37H52N3O5PS
Mol. Weight
681.86
Qty 1
250mg
Qty 2
1g
Appearance
yellowish viscous oil
Solubility
soluble in acetonitrile, dichloromethane
Storage condition
-20°C
References

Aminolink phosphoramidite for oligonucleotide synthesis. DMS(O)MT is a special protective group similar to traditional MMT, but designed as an improved alternative to it. DMS(O)MT aminolink is fully compatible with standard coupling, deblock, and purification protocols. However, DMS(O)MT group is much better suited for DMT-on and cartridge purification of amino-oligonucleotides because of higher stability, and better oligonucleotide recovery. Oligonucleotides containing DMS(O)MT are more stable in solution than MMT analogs.

In case of cartridge purification, DMS(O)MT protection allows for 2-3 fold increase of oligonucleotide yield, making this reagent a unique solution for high-throughput manufacturing of amino-oligonucleotides.

Product citations

  1. Aparin, I.O.; Farzan, V.M.; Veselova, O.A.; Chistov, A.A.; Podkolzin, A.T.; Ustinov, A.V.; Shipulin, G.A.; Formanovsky, A.A.; Korshun, V.A.; Zatsepin, T.S. 1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay. Analyst2016, 141, 1331–1338. doi: 10.1039/c5an01767j