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Cat. Number
DBCO NHS ester
Chemical Name
DBCO NHS ester
Mol. Formula
C25H22N2O5
Mol. Weight
430.45
Qty 1
25mg
Qty 2
50mg
Appearance
off white solid
Solubility
good in DCM, DMF, DMSO
Storage condition
-20°C
References

Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cycloalkynes for strain promoted alkyne azide cycloaddition (spAAC) – a copper free Click chemistry reaction.

This is an amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.

DBCO reacts instantly with azides. The rate of the reaction is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines - this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines