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Cat. Number
HM2076
Chemical Name
二甲双胍 Metformin Hydrochloride
CAS Number
1115-70-4
Mol. Weight
165.62
Qty 1
5g
Qty 2
100g
Synonym
1,1-Dimethylbiguanide Hydrochloride;Dimethylbiguanide hydrochloride; Imidodicaronimidic diamide; N,N-dimethyl-, monohydrochloride; N,N-Dimethylbiguanide hydrochloride
Melting Pt.
223-226°C
References

Metformin exhibits anti-diabetic, anti-hyperglycemic, anti-oxidative, immunosuppressive, chemopreventive, and chemotherapeutic activities. Metformin modulates glucose-6-phosphatase activity, decreasing glucose production and glycogenolysis. Additionally, it inhibits expression of TNF-α in the liver, reversing pathology of fatty liver disease in vivo. In podocytes, metformin activates AMPK and decreases activity of NADPH oxidase and generation of free radicals. In other in vitro models, metformin inhibits expression of MHC molecules and co-stimulatory factors on dendritic cells, preventing antigen presentation. Across several hepatocellular carcinoma cell lines, metformin decreases expression of cyclin D1, cyclin E, and CDK4, inducing G0/G1 phase cell cycle arrest and inhibiting cell proliferation. In vivo, this compound also downregulates expression of c-myc, preventing neoplasia initiation in prostate cancer models.

Clinical trial in human provides evidence that it suppresses colonic epithelial proliferation and rectal ACF formation.