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Cat. Number
HA4400
Chemical Name
丙甲菌素 Alamethicin
CAS Number
27061-78-5
Mol. Formula
C92H150N22O25
Mol. Weight
1964.4
Qty 1
1mg
Qty 2
5mg
Application Notes
99%
Synonym
丙甲菌素;Alamethicin
Solubility
DMSO, Methanol, Ethanol
References

Alamethicin is a channel-forming ionophore. It activates membrane enzymes by disrupting the membrane barriers of sarcolemmal vesicles, which gives substrates and activators access to enzymatic sites in the interior of the vesicles.
Alamethicin is a peptabiol peptide produced by species of Trichoderma. Alamethicin is an antimicrobial peptide (AMP) that disturbs the lipid layer of the cell membrane, aggregating and forming pores and causing cell lysis.

Krauson AJ, He J, Wimley WC. Determining the mechanism of membrane permeabilizing peptides: identification of potent, equilibrium pore-formers. Biochim Biophys Acta. 2012 Jul;1818(7):1625-32. PMID: 22365969.

Huang HW. Molecular mechanism of antimicrobial peptides: the origin of cooperativity. Biochim Biophys Acta. 2006 Sep;1758(9):1292-302. PMID: 16542637.