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Cat. Number
1051
Chemical Name
1051 (神经)鞘磷脂 Sphingomyelin 85187-10-6
CAS Number
85187-10-6
Category
natural,bovine buttermilk
Mol. Formula
C41H83N2O6P
Mol. Weight
731
Qty 1
1g
Appearance
solid
Application Notes
98+% TLC
Synonym
SPM; Ceramide-1-phosphorylcholine
Solubility
ethanol, methanol, chloroform
Storage condition
-20°C
References

This product is a high purity sphingomyelin extracted from bovine buttermilk. Sphingomyelin is found in mammalian cell membranes, especially in the membranes of the myelin sheath. It is the most abundant sphingolipid in mammals and is thought to be found mostly in the exoplasmic leaflet of the membrane although there is also evidence of a sphingomyelin pool in the inner leaflet of the membrane. It is involved in signal transduction and apoptosis.1 An improper ratio of sphingomyelin to ceramide has been shown to be a factor in Niemann-Pick disease2 and neonatal respiratory distress syndrome.3 However, the ratio of sphingomyelin to ceramide is different for different cell types.4 Sphingomyelin is an important amphiphilic component when plasma lipoprotein pools expand in response to large lipid loads or metabolic abnormalities.
1. R. N. Kolesnick, A. Haimovitz-Friedman, Z. Fuks, Biochem Cell Biol., Vol. 72(11-12) pp. 471-474, 1994
2. M. Schmuth, et al., J Invest Dermatol., Vol. 115(3) pp. 459-466, 2000
3. C. St Clair et al., Am J Perinatol., Vol. 25(8) pp. 473-480, 2008,
4. J. Kilkus et al., J Neurochem. Vol. 106(4) pp. 1745-1757, 2008
5. N. Duan RD., J Lipid Res., Vol. 47(1) pp. 154-171, 2006

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