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Cat. Number
H1886
Chemical Name
H1886 N-C8:0-Cyclopropenylceramide
Category
synthetic
Mol. Formula
C27H51NO3
Mol. Weight
437
Qty 1
1mg
Appearance
solid
Application Notes
98+% 1H NMR; HPLC
Synonym
N-C8:0-CPPC; N-[(1R,2S)-2-Hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide; GT 11Activity: Dihydroceramide desaturase inhibitor
Solubility
chloroform, methanol, ethanol
Storage condition
-20°C
References

1. J. Kraveka et al. “Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells” Journal of Biological Chemistry, Vol. 282 pp. 16718-16728, 2007
2. C. Bedia et al. “Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities” Organic Biomolecular Chemistry, Vol. 3 pp. 3707-3712, 2005
3. G. Triola et al. “Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase” Angewandte Chemie International Edition, Vol. 40(10) pp. 1960-1962, 2001
4. G. Triola et al. “Synthesis of Cyclopropene Analogues of Ceramide and Their Effect on Dihydroceramide Desaturase” Journal of Organic Chemistry, Vol. 68(26) pp. 9924-9932, 2003
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