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Cat. Number
H1859
Chemical Name
酶抑制剂 D-MAPP
CAS Number
143492-39-1
Category
synthetic
Mol. Formula
C23H39NO2
Mol. Weight
301
Qty 1
100mg
Appearance
solid
Application Notes
98+% TLC
Synonym
D-erythro-2-Tetradecanoylamino-1-phenyl-1-propanolActivity: alkaline ceramidase inhibitor
Solubility
ethanol
Storage condition
-20°C
References

1. A. Bielawska et al. “(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase” The Journal of Biological Chemistry, vol. 271 pp. 12646-12654, 1996
2. S. Payne et al. “Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts” Cellular Physiology, vol. 180 pp. 263-270, 1999
3. C. Rodriguez-Lafrasse et al. “Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing” International Journal of Cancer, vol. 101 pp. 589-598, 2002
4. N. Auge et al. “Oxidized LDL-Induced Smooth Muscle Cell Proliferation Involves the EGF Receptor/PI-3 Kinase/Akt and the Sphingolipid Signaling Pathways” Athersclerosis, Thrombosis, and Vascular Biology, vol. 22 pp. 1990-1995, 2002