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Cat. Number
H1807-025
Chemical Name
H1807-025 L-threo-Dihydrosphingosine (Safingol) 15639-50-6
CAS Number
15639-50-6
Category
synthetic
Mol. Formula
C18H39NO2
Mol. Weight
301
Qty 1
25mg
Appearance
solid
Application Notes
98+% TLC, GC
Synonym
L-threo-Sphinganine, C18 chain
Solubility
chloroform, methanol, ethanol, DMSO
Storage condition
-20°C
References

1. Darges, et al. “Inhibition of leukotriene B4 (LTB4) in human neutrophils by L-threo-dihydrosphingosine” Adv. Exp. Med. Biol, Vol. 400A pp. 387-392, 1997
2. G. Schwartz, et al. “A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin” Clin. Cancer Res, Vol. 3 pp. 537-543, 1997
3. J. Coward et al. “Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway” Autophagy Vol. 5(2) pp.184-193, 2009
4. M. Dragusin et al. “Metabolism of the unnatural anticancer lipid safingol,L-threo-dihydrosphingosine, in cultured cells” Vol. 44 pp. 1772, 2003
下一个：L-苏式-二氢神经鞘氨醇/沙芬戈 L-threo-Dihydrosphingosine (Safingol)上一个：D-threo-Dihydrosphingosine
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