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| Cat. Number | I7559 |
| Chemical Name | 异甘草素 Isoliquiritigenin |
| CAS Number | 961-29-5 |
| Mol. Formula | C15H12O4 |
| Mol. Weight | 256.25 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Application Notes | ≧98％（HPLC） |
| Synonym | Isoliquiritigenin, natural；(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one ；4,2′,4′-Trihydroxychalcone |
| Storage condition | +4°C |
| References | Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylase (HDAC), VEGFR2, and NF-κB (via inhibition of IκB kinase). In vitro, this compound increases Nrf2 expression. Additionally, isoliquiritigenin downregulates arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX2) and phospholipase A2 (PLA2), increasing mitochondria- and/or caspase-mediated apoptosis, and inhibiting proliferation of cancer cells. |
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