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Cat. Number | I7559 |
Chemical Name | 异甘草素 Isoliquiritigenin |
CAS Number | 961-29-5 |
Mol. Formula | C15H12O4 |
Mol. Weight | 256.25 |
Qty 1 |
5mg |
Qty 2 | 25mg |
Application Notes | ≧98%(HPLC) |
Synonym | Isoliquiritigenin, natural;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one ;4,2′,4′-Trihydroxychalcone |
Storage condition | +4°C |
References | Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylase (HDAC), VEGFR2, and NF-κB (via inhibition of IκB kinase). In vitro, this compound increases Nrf2 expression. Additionally, isoliquiritigenin downregulates arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX2) and phospholipase A2 (PLA2), increasing mitochondria- and/or caspase-mediated apoptosis, and inhibiting proliferation of cancer cells. |