I7559

异甘草素 Isoliquiritigenin

961-29-5

C₁₅H₁₂O₄

256.25

5mg

25mg

≧98％（HPLC）

Isoliquiritigenin, natural；(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one ；4,2′,4′-Trihydroxychalcone

+4°C

Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylase (HDAC), VEGFR2, and NF-κB (via inhibition of IκB kinase). In vitro, this compound increases Nrf2 expression. Additionally, isoliquiritigenin downregulates arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX2) and phospholipase A2 (PLA2), increasing mitochondria- and/or caspase-mediated apoptosis, and inhibiting proliferation of cancer cells.