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Cat. Number
I7559
Chemical Name
异甘草素 Isoliquiritigenin
CAS Number
961-29-5
Mol. Formula
C15H12O4
Mol. Weight
256.25
Qty 1
5mg
Qty 2
25mg
Application Notes
≧98%(HPLC)
Synonym
Isoliquiritigenin, natural;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one ;4,2′,4′-Trihydroxychalcone
Storage condition
+4°C
References

Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylase (HDAC), VEGFR2, and NF-κB (via inhibition of IκB kinase). In vitro, this compound increases Nrf2 expression. Additionally, isoliquiritigenin downregulates arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX2) and phospholipase A2 (PLA2), increasing mitochondria- and/or caspase-mediated apoptosis, and inhibiting proliferation of cancer cells.