当前您的位置:首页>>生物化学试剂>>信号转导>>PPARα Blocking Peptide
Cat. Number
702183139569552
Chemical Name
PPARα Blocking Peptide
References
Synonyms
  • Peroxisome Proliferator-activated Receptor α
Formulation A lyophilized peptide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 384 39-43 (1996).

Kroetz, D.L., Yook, P., Costet, P., et al. Peroxisome proliferator-activated receptor α controls the hepatic CYP4A induction adaptive response to starvation and diabetes. J Biol Chem 273 31581-31589 (1998).

Forman, B.M., Chen, J., and Evans, R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc Natl Acad Sci USA 94 4312-4317 (1997).

Sher, T., Yi, H., McBride, O.W., et al. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32 5598-5604 (1993).

Gearing, K.L., Crickmore, A., and Gustafsson, J. Structure of the mouse peroxisome proliferator activated receptor a gene. Biochem Biophys Res Commun 199 255-263 (1994).

Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

Martin, G., Schoonjans, K., Lefevbre, A., et al. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. J Biol Chem 272 28210-28217 (1997).

Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272 3406-3410 (1997).

Mukherjee, R., Jow, L., Noonan, D., et al. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51 157-166 (1994).

Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

Show all 10 Hide all but first 3
Size Global Purchasing
1 ea  

Description

Each vial contains 200 µg of lyophilized peptide derived from the human/mouse/rat PPARα sequence (amino acids 22-36; PLSEEFLQEMGNIQE).1 This peptide was used as an antigen for production of Cayman’s PPARα polyclonal antibody (Catalog No. 101710) and can be used in conjunction with this antibody to block protein-antibody complex formation during immunohistochemical analysis for this protein.

1 Mukherjee, R., Jow, L., Noonan, D., et al. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51 157-166 (1994).