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Cat. Number
702025728359752
Chemical Name
PPARδ Western Ready Control
References
Synonyms
  • Peroxisome Proliferative Activated Receptor δ
  • Nuclear Hormone Receptor 1
  • FAAR
  • PPARβ
  • NUC1
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Dreyer, C., Krey, G., Keller, H., et al. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68 879-887 (1992).

Lim, H., and Dey, S.K. PPARδ functions as a prostacyclin receptor in blastocyst implantation. Trends Endocrinol Metab 11(4) 137-142 (2000).

Wang, Y., Lee, C., Tiep, S., et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113 159-170 (2003).

He, T., Chan, T.A., Vogelstein, B., et al. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99 335-345 (1999).

Berger, J., Leibowitz, M.D., Doebber, T.W., et al. Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects. J Biol Chem 274 6718-6725 (1999).

Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

Amri, E., Bonino, F., Ailhaud, G., et al. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. J Biol Chem 270 2367-2371 (1995).

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Size Global Purchasing
1 ea  

Description

Application(s): positive control for WB · Source: human recombinant N-terminal His-tagged protein over expressed in Sf21 insect cells · Mr: 54 kDa · PPARδ is one of three PPAR subtypes that possess a domain structure common to other members of the nuclear receptor gene family. It was first cloned from Xenopus laevis and named PPARb.1 PPARδ is ubiquitously expressed but is particularly abundant in tissues such as liver, intestine, kidney, abdominal adipose, and skeletal muscle, all of which are involved in lipid metabolism.2 PPARδ is a mediator of diverse physiological functions including lipid and cholesterol homeostasis, embryo implantation, and cancer development.3,4,5,6 Most recently, attention has been focused on the role of PPARδ in obesity.7

1 Dreyer, C., Krey, G., Keller, H., et al. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68 879-887 (1992).

2 Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

3 Amri, E., Bonino, F., Ailhaud, G., et al. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. J Biol Chem 270 2367-2371 (1995).

4 Berger, J., Leibowitz, M.D., Doebber, T.W., et al. Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects. J Biol Chem 274 6718-6725 (1999).

5 missing reference text

6 He, T., Chan, T.A., Vogelstein, B., et al. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99 335-345 (1999).

7 Wang, Y., Lee, C., Tiep, S., et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113 159-170 (2003).