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Cat. Number

702025728359752

Chemical Name

PPARδ Western Ready Control

References

Synonyms	Peroxisome Proliferative Activated Receptor δ Nuclear Hormone Receptor 1 FAAR PPARβ NUC1
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Dreyer, C., Krey, G., Keller, H., et al. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68 879-887 (1992).

Lim, H., and Dey, S.K. PPARδ functions as a prostacyclin receptor in blastocyst implantation. Trends Endocrinol Metab 11(4) 137-142 (2000).

Wang, Y., Lee, C., Tiep, S., et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113 159-170 (2003).

He, T., Chan, T.A., Vogelstein, B., et al. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99 335-345 (1999).

Berger, J., Leibowitz, M.D., Doebber, T.W., et al. Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects. J Biol Chem 274 6718-6725 (1999).

Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

Amri, E., Bonino, F., Ailhaud, G., et al. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. J Biol Chem 270 2367-2371 (1995).

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Size	Global Purchasing
1 ea

Description

Application(s): positive control for WB · Source: human recombinant N-terminal His-tagged protein over expressed in Sf21 insect cells · M_r: 54 kDa · PPARδ is one of three PPAR subtypes that possess a domain structure common to other members of the nuclear receptor gene family. It was first cloned from Xenopus laevis and named PPARb.¹ PPARδ is ubiquitously expressed but is particularly abundant in tissues such as liver, intestine, kidney, abdominal adipose, and skeletal muscle, all of which are involved in lipid metabolism.² PPARδ is a mediator of diverse physiological functions including lipid and cholesterol homeostasis, embryo implantation, and cancer development.^3,4,5,6 Most recently, attention has been focused on the role of PPARδ in obesity.⁷

1 Dreyer, C., Krey, G., Keller, H., et al. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68 879-887 (1992).

2 Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

3 Amri, E., Bonino, F., Ailhaud, G., et al. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. J Biol Chem 270 2367-2371 (1995).

4 Berger, J., Leibowitz, M.D., Doebber, T.W., et al. Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects. J Biol Chem 274 6718-6725 (1999).

5 missing reference text

6 He, T., Chan, T.A., Vogelstein, B., et al. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99 335-345 (1999).

7 Wang, Y., Lee, C., Tiep, S., et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113 159-170 (2003).

下一个：PPARδ Transcription Factor Assay Kit上一个：Rosiglitazone-d5 Maleate

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