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Cat. Number
702016892702384
Chemical Name
Rosiglitazone-d5 Maleate
References
Molecular Formula C22H18D5N3O7S
Formula Weight 412.9
Purity >99% deuterated product
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(=O)​\C=C\C(=O)​O.O=C1SC(Cc2ccc(OCCN(C)​c3ccccn3)​cc2)​C(=O)​N1
Size Global Purchasing
1 mg  
5 mg  
10 mg  

Description

Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class. Like other thiazolidinediones, its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor κ-B (NF-κB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone.