当前您的位置:首页>>生物化学试剂>>信号转导>>Wy 14643
Cat. Number
701936324364409
Chemical Name
Wy 14643
References
Synonyms
  • Pirinixic Acid
Formal Name [[4-​chloro-​6-​[(2,​3-​dimethylphenyl)amino]-​2-​pyrimidinyl]thio]-​acetic acid
CAS Number 50892-23-4
Molecular Formula C14H14ClN3O2S
Formula Weight 323.8
Formulation A crystalline solid
Purity >98%
λmax 244, 292 nm
Stability 2 years
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
OC(=O)​CSc1nc(cc(Cl)​n1)​Nc1cccc(C)​c1C

Background Reading

Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 384 39-43 (1996).

Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272 3406-3410 (1997).

Keller, H., Devchand, P.R., Perroud, M., et al. PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem 378 651-655 (1997).

Schmidt, A., Endo, N., Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 6 1634-1641 (1992).

Staels, B., Koenig, W., Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 393 790-793 (1998).

Hsu, M., Palmer, C.N.A., Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators. Mol Pharmacol 48 559-567 (1995).

Show all 6 Hide all but first 3
Size Global Purchasing
5 mg  
10 mg  
50 mg  
250 mg  

Description

Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARα,1,2,3 it activates PPARγ as well.4 Activation of PPARδ by Wy 14643 is also observed,5 but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.6

1 Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 384 39-43 (1996).

2 Hsu, M., Palmer, C.N.A., Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators. Mol Pharmacol 48 559-567 (1995).

3 Staels, B., Koenig, W., Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 393 790-793 (1998).

4 Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272 3406-3410 (1997).

5 Schmidt, A., Endo, N., Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 6 1634-1641 (1992).

6 Keller, H., Devchand, P.R., Perroud, M., et al. PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem 378 651-655 (1997).

下一个:Troglitazone上一个:PSB 1114