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Cat. Number
JT4140
Chemical Name
EB 47
CAS Number
366454-36-6
Mol. Formula
C24H27N9O6.2HCl
Mol. Weight
610.45
Qty 1
10mg
Qty 2
50mg
Appearance
White solid
Application Notes
>99%
Synonym
5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo -1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl ]-5'-oxoadenosine dihydrochloride
Solubility
Soluble to 5 mM in water and to 50 mM in DMSO
Storage condition
Store at -20°C
References

Jagtap et al (2004) The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). Bioorg.Med.Chem.Lett. 14 81. PMID: 14684303.

Gaymes et al (2009) Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 94 638.

Ferraris et al (2010) Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J.Med.Chem. 53 4561. PMID: 20364863.

 

HPLC: Shows 99.4% purity
1H NMR: Consistent with structure
Mass Spectrum: Consistent with structure
Microanalysis
               Carbon Hydrogen Nitrogen
Theoretical 43.38     5.31     18.97
Found        43.26     5.37     18.95

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