EB-47 366454-36-6_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

服务热线：13917250134「同微信」

您的位置：首页>>生化试剂>>小分子化合物>>EB-47 366454-36-6

产品中心

/ Products Classification 点击展开+

Cat. Number

HB-114714

Chemical Name

EB-47 366454-36-6

CAS Number

366454-36-6

Mol. Formula

C24H27N9O6.2HCl

Mol. Weight

610.45

Qty 1

10mg

Qty 2

50mg

Appearance

White solid

Application Notes

>99%

Synonym

5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo -1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl ]-5'-oxoadenosine dihydrochloride

Solubility

Soluble to 5 mM in water and to 50 mM in DMSO

Storage condition

Store at -20°C

References

EB-47是一种有效的PARP-1/ARTD-1 选择性抑制剂，IC50 值为 45 nM，对 ARTD5 的IC50 值为 410 nM，表现出温和的药效。EB-47 模拟底物 NAD+，从烟酰胺延伸至腺苷亚区结合。

订购信息:

产品信息：

CAS RN	366454-36-6
Product Name	EB-47
Molecular Formula	C₂₄H₂₇N₉O₆
Molecular Weight	537.53
IUPAC Name	2-[4-[(2R,3R,4S,5S)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carbonyl]piperazin-1-yl]-N-(1-oxo-2,3-dihydroisoindol-4-yl)acetamide
InChI	InChI=1S/C24H27N9O6/c25-20-16-21(28-10-27-20)33(11-29-16)24-18(36)17(35)19(39-24)23(38)32-6-4-31(5-7-32)9-15(34)30-14-3-1-2-12-13(14)8-26-22(12)37/h1-3,10-11,17-19,24,35-36H,4-9H2,(H,26,37)(H,30,34)(H2,25,27,28)/t17-,18+,19-,24+/m1/s1
SMILES	C1CN(CCN1CC(=O)NC2=CC=CC3=C2CNC3=O)C(=O)C4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O
Synonyms	5’-Deoxy-5’-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5’-oxoadenosine; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-_x000B_ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide; 2-[4-[(2R,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carbonyl]piperazin-1-yl]-N-(1-oxo-2,3-dihydroisoindol-4-yl)acetamide