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| Cat. Number | E7309 |
| Chemical Name | E7309 ESCULETIN 305-01-1 |
| CAS Number | 305-01-1 |
| Mol. Formula | C9H6O4 |
| Mol. Weight | 178.14 |
| Qty 1 |
500mg |
| Qty 2 | 1g |
| Appearance | Light Yellow Crystalline Powder |
| Application Notes | ≥99% |
| Synonym | 6,7-Dihydroxycoumarin, Cichorigenin |
| Melting Pt. | 268-270°C |
| Solubility | Soluble in dil alkalies, hot alcohol or glacial acetic acid. Insoluble in ether or boiling water. |
| Storage condition | Ambient |
| References | Esculetin is a coumarin lactone found in chicory and other plants; it exhibits anticoagulant, anti-obesity, anti-hyperlipidemic, anti-inflammatory, anticancer, antioxidative, and neuroprotective activities. Esculetin decreases levels of NO, PPARγ, TNF-α, and MCP-1 and increases levels of heme oxygenase 1 (HO-1) in macrophages. In animal models of Parkinson’s disease, esculetin inhibits MPTP-induced neurotoxicity and neuronal apoptosis. In high fat diet-fed rats, this compound decreases body weight, triglyceride levels, total cholesterol, and glucose levels. Additionally, esculetin induces cell cycle arrest, DNA fragmentation, activation of caspases 3 and 9, reduction of the mitochondrial membrane potential, and apoptosis in acute promyelocytic leukemia (APL) cells. Esculetin also inhibits proliferation of colon cancer cells by directly inhibiting β-catenin. This compound also acts as a radical scavenger in vitro. ReferencesKim Y, Park Y, Namkoong S, et al. Esculetin inhibits the inflammatory response by inducing heme oxygenase-1 in cocultured macrophages and adipocytes. Food Funct. 2014 Aug 20;5(9):2371-7. PMID: 25088305. Rubio V, Calviño E, García-Pérez A, et al. Human acute promyelocytic leukemia NB4 cells are sensitive to esculetin through induction of an apoptotic mechanism. Chem Biol Interact. 2014 Jul 1;220C:129-139. PMID: 24995577. Medina ME, Galano A, Alvarez-Idaboy JR. Theoretical study on the peroxyl radicals scavenging activity of esculetin and its regeneration in aqueous solution. Phys Chem Chem Phys. 2014 Jan 21;16(3):1197-207. PMID: 24292723. Lee SY, Lim TG, Chen H, et al. Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin. Cancer Prev Res (Phila). 2013 Dec;6(12):1356-64. PMID: 24104353. Karmase A, Birari R, Bhutani KK. Evaluation of anti-obesity effect of Aegle marmelos leaves. Phytomedicine. 2013 Jul 15;20(10):805-12. PMID: 23632084. Subramaniam SR, Ellis EM. Neuroprotective effects of umbelliferone and esculetin in a mouse model of Parkinson's disease. J Neurosci Res. 2013 Mar;91(3):453-61. PMID: 23184853. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
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