| References |
| Formal Name |
3-(5-[1,2]dithiolan-3yl-pentanoylamino)-propyl]-amide |
| CAS Number |
691410-93-2 |
| Molecular Formula |
C19H34N2O2S4 |
| Formula Weight |
450.7 |
| Formulation |
A crystalline solid |
| Purity |
>98% |
| λmax |
331 nm |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
O=C(CCCCC1SSCC1)NCCCNC(=O)CCCCC1SSCC1
|
Background Reading
Gruzman, A., Hidmi, A., Katzhendler, J., et al. Synthesis and characterization of new and potent α-lipoic acid derivatives. Bioorg Med Chem 12 1183-1190 (2004).
Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).
| Size |
Global Purchasing |
| 5 mg |
|
| 10 mg |
|
| 50 mg |
|
| 100 mg |
|
Description
α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle and acts as a general antioxidant.1 AN-7 is a more lipophilic analog of α-lipoic acid with enhanced potency and 1.5-fold increased maximal capacity to stimulate glucose transport into myocytes.2 This identifies the analogs of lipoic acid as potential new treatments for diabetes.
1
Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).
2
Gruzman, A., Hidmi, A., Katzhendler, J., et al. Synthesis and characterization of new and potent α-lipoic acid derivatives. Bioorg Med Chem 12 1183-1190 (2004).
|
